Is Rejuran worth it in Seoul? What to know before you book

1. What kind of treatment is Rejuran?

Rejuran is a Korean skin booster: a DNA-derived ingredient from salmon (polynucleotides) injected into the upper layer of the skin. Unlike filler, it doesn’t add volume. It aims to improve the skin itself, its texture, fine lines and elasticity.

That also tells you when it’s the wrong tool. If what bothers you is hollow cheeks or a jawline that has dropped, Rejuran is unlikely to be the answer. Sorting your concern into “skin quality” or “volume and lift” before the consultation makes the conversation far more useful.

2. What changes have studies reported?

Across the published studies, the consistent finding is improvement in fine lines, texture and elasticity. A 2024 systematic review pulled together nine studies of this type of injection, covering 219 people, and several reported better wrinkles, texture and firmness. Seven of the nine were carried out in Korea.

A 2026 study followed 42 people who had under-eye injections of the same type for six months. Satisfaction peaked about three months after two sessions and eased slightly by six months. That study used a different brand, not Rejuran.

*Based on published research. Results and recovery vary from person to person.

3. The evidence is still small

To be candid, the evidence behind Rejuran is not as solid as its popularity suggests. The 2024 review rated its own studies as low to moderate quality and concluded that more rigorous research is needed.

There is also a detail most articles skip. The 2014 Korean trial that compared this type of injection directly with hyaluronic acid filler was retracted in 2016 for failing to disclose manufacturer funding, yet the review still counts it. Another paper the review cites was retracted in 2024 over its photographs.

None of this means Rejuran doesn’t work. It means claims like “better than filler” or “guaranteed regeneration” are running ahead of the evidence.

4. How many sessions, and how far apart?

Korean dermatologists most often recommend three sessions, four weeks apart. In a 2023 survey of 235 Korean board-certified dermatologists, 88% said they use this type of injection, and “three sessions, four weeks apart” was the most common schedule.

Roughly eight in ten (79%) also combine it with device treatments such as radiofrequency or ultrasound lifting (HIFU). When you compare quotes, check whether you are looking at Rejuran alone or a bundled package.

*Based on published research. Results and recovery vary from person to person.

5. Planning it around a short trip

If you are in Seoul for about a week, you won’t finish a full course in one trip. That usually leaves three options: have the first session in Seoul and continue at home, return to Seoul a few weeks later, or have a single session and see how your skin responds. Which one suits you depends on your skin and your calendar, so ask before you lock in flights.

Also keep in mind that the change is usually clearest after you are home. Decide in advance how you will take comparison photos and who you will contact if a question comes up.

6. Questions worth bringing to the consultation

Consultations are often shorter than people expect, so it helps to arrive with questions written down. Ask whether the product and amount match your quote, how many sessions are recommended for your skin, and whether the price includes numbing, any device treatment and a follow-up visit. Find out which reactions are normal in the first few days and when you should get in touch.

Because the ingredient comes from salmon, mention any fish allergy at the start. COMEDI helps you organise these questions and compare quotes on the same terms; whether to go ahead is decided with the clinician who examines you.

7. The bottom line

Rejuran is worth considering if your goal is gradually refining texture and fine lines. It isn’t a one-visit treatment, and its evidence is still growing, so set your expectations at natural change rather than a dramatic one. Rather than squeezing sessions into a holiday, start with a plan that your actual schedule can support.

FAQ: Does one Rejuran session make a difference?

Some people notice a change after one Rejuran session, but the schedule Korean dermatologists recommend most is three sessions four weeks apart. In the under-eye study, satisfaction was highest after the second session. If one visit is all you can manage, say so at the start of the consultation.

FAQ: Does Rejuran hurt, and will I swell?

Rejuran can leave the injection area swollen, red, sore or itchy for a short time. In the studies collected by the 2024 review, these reactions usually settled within a week, and no serious side effects were reported. The studies were small, though, so rarer problems can’t be ruled out.

FAQ: Is Rejuran safer than filler?

There isn’t enough evidence to say Rejuran is safer than filler. The main trial comparing the two was retracted. They also solve different problems, so the better first question is which one fits your concern.