Is Rejuran worth it in Seoul? What to know before you book

1. What does Rejuran actually do?

Rejuran is a Korean skin booster made from a DNA-derived ingredient from salmon (polynucleotides). It is injected into the upper layer of the skin to improve the skin itself: texture, fine lines and firmness.

It does not add volume the way filler does. That is why it suits some concerns better than others:

• Usually a good match: rough texture, fine lines around the eyes and cheeks, skin that looks tired or thin
• Usually not the answer: hollow cheeks, a dropped jawline, wanting a visible lift

Knowing which side your concern falls on makes the consultation much more useful.

2. How much difference has research found?

Studies consistently report gradual improvement in fine lines, texture and firmness. A 2024 systematic review gathered nine studies of this type of injection, involving 219 people, and several found better wrinkles, texture and elasticity. Seven of the nine were done in Korea.

Timing matters too. A 2026 study followed 42 people who had under-eye injections of the same type. Their satisfaction rose after the first session, peaked about three months after the second, and eased a little by six months. That study used a different brand, but it gives a realistic picture: the result shows up over months, not overnight.

*Based on published research. Results and recovery vary from person to person.

3. How many sessions do Korean clinics recommend?

The most common recommendation is three sessions, four weeks apart. In a 2023 survey of 235 Korean board-certified dermatologists, 88% said they use this type of injection, and three sessions at four-week intervals was the schedule they recommended most.

About eight in ten of them (79%) also pair it with device treatments such as radiofrequency or ultrasound lifting (HIFU). So when two clinics quote very different prices, check first whether you are comparing Rejuran alone or a combined package.

*Based on published research. Results and recovery vary from person to person.

4. I’m only in Seoul for a week. What then?

A one-week trip won’t cover a full course, and that is fine as long as you plan for it. Most visitors end up choosing one of three routes:

• Start in Seoul, continue at home: have the first session here and finish the course with a clinic near you
• Come back: return to Seoul about four weeks later for the next session
• Try once: have a single session and see how your skin responds before committing

Which route suits you depends on your skin and your calendar, so raise it before you book flights. And because the change is clearest a few months later, take a few well-lit photos before treatment. You will want them for comparison once you are home.

5. Why the evidence is promising but not settled

To be candid, Rejuran’s evidence is thinner than its popularity suggests. The 2024 review rated its own studies as low to moderate quality and called for more rigorous research.

One detail rarely makes it into marketing. The 2014 Korean trial that compared this type of injection head-to-head with hyaluronic acid filler was retracted in 2016 because it did not disclose manufacturer funding, yet the review still counts it. Another paper the review cites was retracted in 2024 over its photographs.

That doesn’t mean Rejuran doesn’t work. It means phrases like “better than filler” or “guaranteed regeneration” are ahead of the evidence, and a natural, gradual change is the fair expectation.

6. What to ask at the consultation

Consultations are often shorter than you expect, so bring your questions written down:

• Is the product and amount the same as in my quote?
• How many sessions do you recommend for my skin, and what if I can only do one here?
• Does the price include numbing, any device treatment and a follow-up?
• What reactions are normal over the next few days, and when should I contact you?
• How can I reach you from abroad if I have a question?

Because the ingredient comes from salmon, mention any fish allergy right at the start. COMEDI can help you prepare these questions and compare clinics on the same terms; whether to go ahead is decided with the clinician who examines you.

7. The bottom line

Rejuran is a reasonable choice if you want gradual improvement in texture and fine lines and can plan for more than one session. Set your expectations at a natural change, not a dramatic one, and build the plan around the dates you actually have.